BPA; An Endocrine Disruptor Induced Biochemical Changes and Histopathological Damage in the Kidneys of Rats (Rattus norvegicus)

• Naila Hameed

  Cell & Molecular Biology Lab, Institute of Zoology, University of the Punjab, Q-A Campus, Lahore, 54590, Pakistan.

  Author

• Tasleem Akhtar

  Department of Pharmacology, University of Health Sciences, Lahore, 54600, Pakistan

  Author

  https://orcid.org/0000-0002-4984-4373

• Nadeem Sheikh

  Cell & Molecular Biology Lab, Institute of Zoology, University of the Punjab, Q-A Campus, Lahore, 54590, Pakistan

  Author

  https://orcid.org/0000-0001-9503-9538

Background: Xenoestrogens are chemical compounds that are similar to estrogen in effect but not in structure. Bisphenol A is an endocrine disruptor, that mimics the action of endogenous estrogen and activates the estrogen receptor. It is produced in large volumes and incorporated in many plastic industries worldwide. BPA is extensively used in food and beverages. The ubiquitous and extensive use of BPA containing products results in high human exposure, and its effects on the human body are of great concern. The aim of the present study was to evaluate the effects of BPA on biochemical and histopathological parameters of the kidney.

Material and Methods: Forty adult male rats were assigned into five groups of eight rats each. One group was served as a control and other groups were treated with BPA. Rats were administered orally with different doses of BPA 10mg/Kg and 25mg/Kg for 6 and 12 weeks, respectively. All doses of BPA were dissolved in corn oil and orally administered to rats. After 6 and 12 weeks, blood and kidney samples were collected for evaluation of biochemical parameters and histopathological analyses.

Results: Serum levels of urea and creatinine were significantly increased, and uric acid levels in serum were increased but not significantly. The biochemical parameters variations were confirmed by histopathological investigations. BPA induced toxicity may lead to harmful health effects.

Conclusion: Results showed that the oral administration of BPA significantly affects biochemical parameters and renal tissue architecture.

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