Psoriasis: An Overview of its Pathogenesis and Available Treatment Modalities

• Zari Salahuddin

  Department of Pharmacology, University of Health Sciences, Lahore, 54600, Pakistan

  Author

• Muhammad Usman Ali Khan

  Department of Pharmacology, University of Health Sciences, Lahore, 54600, Pakistan

  Author

• Tasleem Akhtar

  Department of Pharmacology, University of Health Sciences, Lahore, 54600, Pakistan

  Author

  https://orcid.org/0000-0002-4984-4373

Psoriasis is a chronic inflammatory and genetic disease that mainly involves skin with some complicated forms extending to other body systems. The disease is common with genetic predisposition as one of the major etiologies. It is known to occur because of immune system aberration involving helper T cells mainly and is thus treated on similar lines with most of the drugs belonging to immunomodulator class like steroids, calcineurin inhibitors, methotrexate, and various others like retinoids. Disease pathology has a new area of research advancement focused on oxidative stress. It has been suggested that reactive oxygen species have a considerable role in the cascade of pathological features. The disease shows relapses and remissions seldom showing a remarkable or complete recovery. A therapy which can completely resolve the cosmetic and other important symptoms is still a food for research. The dimensions of research have also been inclined to nano particles as treatment options over past few years. In this review, our key objective is to highlight the complexity and clinical diversity of this multifaceted disorder, its pathogenesis, and the potential of state-of-the-art treatment options.

1. Zari Salahuddin, Department of Pharmacology, University of Health Sciences, Lahore, 54600, Pakistan

   Department of Pharmacology, University of Health Sciences

2. Muhammad Usman Ali Khan, Department of Pharmacology, University of Health Sciences, Lahore, 54600, Pakistan

   Department of Pharmacology, University of Health Sciences

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