Sub-Chronic Effects of Sodium Metabisulfite on the Intestinal Microarchitecture of Mice

• Sana Fatima

  Department of Microbiology, University of Health Sciences, Lahore, 54590, Pakistan

  Author

• Hussain Khan

  Department of Zoology, University of Okara, Okara, 56300, Punjab, Pakistan

  Author

• Ayesha Majid

  Department of Zoology, University of Okara, Okara, 56300, Punjab, Pakistan

  Author

  https://orcid.org/0000-0002-2252-6439

• Muhammad Atif

  Department of Zoology, University of Okara, Okara, 56300, Punjab, Pakistan

  Author

• Azka Zafar

  Department of Zoology, University of Okara, Okara, 56300, Punjab, Pakistan

  Author

• Adil Farooq

  Department of Zoology, University of Okara, Okara, 56300, Punjab, Pakistan

  Author

• Mirza Fahad Baig

  Department of Microbiology, University of Health Sciences, Lahore, 54590, Pakistan

  Author

• Asma Rashid Khan

  Govt Graduate College for Women Township, Lahore, Pakistan

  Author

Background: Sodium metabisulfite (SM) is commonly used with varying concentrations as a preservative, sewage treatment chemical, and in other commercial consumer products etc. It is reported to pose series of health hazards affecting various vital organs. The current study was aimed to find histological alterations in the intestine with sub-chronic exposure of SM in albino mice.

Materials and Methods: Ten mice were orally given SM (1.2 mg/kg mixed in 0.1 ml corn oil) for 21 days while ten mice were kept in the control group (no SM). All the mice were dissected, and small intestine pieces were excised and processed for histological sectioning and staining.

Results: SM disrupts the outer wall of villi and microvilli of the small intestine. Moreover, a narrow lumen and few mitotic figures were seen in the intestinal glands.

Conclusion: The results concludes that SM is a potential source of major organ’s defects and hence its usage should be lessened to improve the health status.

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